Modeling Cardiac Congenital Diseases : From Mathematic Tools to Human Induced Pluripotent Stem Cells
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Cardiac congenital diseases are rare inherited disorders characterized by anatomical malformations and/or by electrophysiological abnormalities, both affecting the whole heart function.
In order to clarify the underlying pathophysiological mechanisms, experimental modeling has been proposed through in silico, in vitro, and/or in vivo simulations.
Bioinformatics, transgenesis, heterologous expression systems, mammalian models, and, recently, pluripotent stem cells have been advanced to effectively recapitulate several human congenital diseases (such as Brugada syndrome, CPVT, LQTs, and ARVC) and, potentially, provide new insights into their pathomechanisms for novel therapeutic perspectives.
American Psychological Association (APA)
Iop, Laura. 2014. Modeling Cardiac Congenital Diseases : From Mathematic Tools to Human Induced Pluripotent Stem Cells. Conference Papers in Science،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-466532
Modern Language Association (MLA)
Iop, Laura. Modeling Cardiac Congenital Diseases : From Mathematic Tools to Human Induced Pluripotent Stem Cells. Conference Papers in Science No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-466532
American Medical Association (AMA)
Iop, Laura. Modeling Cardiac Congenital Diseases : From Mathematic Tools to Human Induced Pluripotent Stem Cells. Conference Papers in Science. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-466532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466532