Gene Modification of Mesenchymal Stem Cells and Articular Chondrocytes to Enhance Chondrogenesis
Joint Authors
Strappe, Padraig
Gurusinghe, Saliya
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Current cell based treatment for articular cartilage and osteochondral defects are hampered by issues such as cellular dedifferentiation and hypertrophy of the resident or transplanted cells.
The reduced expression of chondrogenic signalling molecules and transcription factors is a major contributing factor to changes in cell phenotype.
Gene modification of chondrocytes may be one approach to redirect cells to their primary phenotype and recent advances in nonviral and viral gene delivery technologies have enabled the expression of these lost factors at high efficiency and specificity to regain chondrocyte function.
This review focuses on the various candidate genes that encode signalling molecules and transcription factors that are specific for the enhancement of the chondrogenic phenotype and also how epigenetic regulators of chondrogenesis in the form of microRNA may also play an important role.
American Psychological Association (APA)
Gurusinghe, Saliya& Strappe, Padraig. 2014. Gene Modification of Mesenchymal Stem Cells and Articular Chondrocytes to Enhance Chondrogenesis. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-466571
Modern Language Association (MLA)
Gurusinghe, Saliya& Strappe, Padraig. Gene Modification of Mesenchymal Stem Cells and Articular Chondrocytes to Enhance Chondrogenesis. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-466571
American Medical Association (AMA)
Gurusinghe, Saliya& Strappe, Padraig. Gene Modification of Mesenchymal Stem Cells and Articular Chondrocytes to Enhance Chondrogenesis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-466571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466571