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Detection of Fetomaternal Genotype Associations in Early-Onset Disorders : Evaluation of Different Methods and Their Application to Childhood Leukemia
Joint Authors
Richer, Chantal
Sinnett, Daniel
Healy, Jasmine
Bourgey, Mathieu
Roy-Gagnon, Marie-Helene
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-09
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Several designs and analytical approaches have been proposed to dissect offspring from maternal genetic contributions to early-onset diseases.
However, lack of parental controls halts the direct verification of the assumption of mating symmetry (MS) required to assess maternally-mediated effects.
In this study, we used simulations to investigate the performance of existing methods under mating asymmetry (MA) when parents of controls are missing.
Our results show that the log-linear, likelihood-based framework using a case-triad/case-control hybrid design provides valid tests for maternal genetic effects even under MA.
Using this approach, we examined fetomaternal associations between 29 SNPs in 12 cell-cycle genes and childhood pre-B acute lymphoblastic leukemia (ALL).
We identified putative fetomaternal effects at loci CDKN2A rs36228834 (P=.017) and CDKN2B rs36229158 (P=.022) that modulate the risk of childhood ALL.
These data further corroborate the importance of the mother's genotype on the susceptibility to early-onset diseases.
American Psychological Association (APA)
Healy, Jasmine& Bourgey, Mathieu& Richer, Chantal& Sinnett, Daniel& Roy-Gagnon, Marie-Helene. 2010. Detection of Fetomaternal Genotype Associations in Early-Onset Disorders : Evaluation of Different Methods and Their Application to Childhood Leukemia. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-466572
Modern Language Association (MLA)
Healy, Jasmine…[et al.]. Detection of Fetomaternal Genotype Associations in Early-Onset Disorders : Evaluation of Different Methods and Their Application to Childhood Leukemia. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-13.
https://search.emarefa.net/detail/BIM-466572
American Medical Association (AMA)
Healy, Jasmine& Bourgey, Mathieu& Richer, Chantal& Sinnett, Daniel& Roy-Gagnon, Marie-Helene. Detection of Fetomaternal Genotype Associations in Early-Onset Disorders : Evaluation of Different Methods and Their Application to Childhood Leukemia. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-13.
https://search.emarefa.net/detail/BIM-466572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466572