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Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis
Joint Authors
Patrignani, Claudia
Graziani, Andrea
Perego, Beatrice
Porporato, Paolo E.
Surico, Daniela
Surico, Nicola
Gregnanin, Ilaria
Filigheddu, Nicoletta
Galli, Licia
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-29, 29 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-10
Country of Publication
Egypt
No. of Pages
29
Main Subjects
Abstract EN
Endometriosis, defined as the presence of endometrial tissue outside the uterus, is a common gynecological disease with poorly understood pathogenesis.
MicroRNAs are members of a class of small noncoding RNA molecules that have a critical role in posttranscriptional regulation of gene expression by repression of target mRNAs translation.
We assessed differentially expressed microRNAs in ectopic endometrium compared with eutopic endometrium in 3 patients through microarray analysis.
We identified 50 microRNAs differentially expressed and the differential expression of five microRNAs was validated by real-time RT-PCR in other 13 patients.
We identified in silico their predicted targets, several of which match the genes that have been identified to be differentially expressed in ectopic versus eutopic endometrium in studies of gene expression.
A functional analysis of the predicted targets indicates that several of these are involved in molecular pathways implicated in endometriosis, thus strengthening the hypothesis of the role of microRNAs in this pathology.
American Psychological Association (APA)
Filigheddu, Nicoletta& Gregnanin, Ilaria& Porporato, Paolo E.& Surico, Daniela& Perego, Beatrice& Galli, Licia…[et al.]. 2010. Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-29.
https://search.emarefa.net/detail/BIM-466575
Modern Language Association (MLA)
Filigheddu, Nicoletta…[et al.]. Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-29.
https://search.emarefa.net/detail/BIM-466575
American Medical Association (AMA)
Filigheddu, Nicoletta& Gregnanin, Ilaria& Porporato, Paolo E.& Surico, Daniela& Perego, Beatrice& Galli, Licia…[et al.]. Differential Expression of MicroRNAs between Eutopic and Ectopic Endometrium in Ovarian Endometriosis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-29.
https://search.emarefa.net/detail/BIM-466575
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466575