Alzheimer's Disease and the Amyloid Cascade Hypothesis : A Critical Review
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Since 1992, the amyloid cascade hypothesis has played the prominent role in explaining the etiology and pathogenesis of Alzheimer's disease (AD).
It proposes that the deposition of β-amyloid (Aβ) is the initial pathological event in AD leading to the formation of senile plaques (SPs) and then to neurofibrillary tangles (NFTs), neuronal cell death, and ultimately dementia.
While there is substantial evidence supporting the hypothesis, there are also limitations: (1) SP and NFT may develop independently, and (2) SPs and NFTs may be the products rather than the causes of neurodegeneration in AD.
In addition, randomized clinical trials that tested drugs or antibodies targeting components of the amyloid pathway have been inconclusive.
This paper provides a critical overview of the evidence for and against the amyloid cascade hypothesis in AD and provides suggestions for future directions.
American Psychological Association (APA)
Reitz, Christiane. 2012. Alzheimer's Disease and the Amyloid Cascade Hypothesis : A Critical Review. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-466606
Modern Language Association (MLA)
Reitz, Christiane. Alzheimer's Disease and the Amyloid Cascade Hypothesis : A Critical Review. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-466606
American Medical Association (AMA)
Reitz, Christiane. Alzheimer's Disease and the Amyloid Cascade Hypothesis : A Critical Review. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-466606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466606