Copper Modulation as a Therapy for Alzheimer's Disease?
Joint Authors
Hidalgo, Juan
Comes, Gemma
Adlard, Paul A.
Manso, Yasmina
Bush, Ashley I.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The role of metals in the pathophysiology of Alzheimer's disease (AD) has gained considerable support in recent years, with both in vitro and in vivo data demonstrating that a mis-metabolism of metal ions, such as copper and zinc, may affect various cellular cascades that ultimately leads to the development and/or potentiation of AD.
In this paper, we will provide an overview of the preclinical and clinical literature that specifically relates to attempts to affect the AD cascade by the modulation of brain copper levels.
We will also detail our own novel animal data, where we treated APP/PS1 (7-8 months old) mice with either high copper (20 ppm in the drinking water), high cholesterol (2% supplement in the food) or a combination of both and then assessed β-amyloid (Aβ) burden (soluble and insoluble Aβ), APP levels and behavioural performance in the Morris water maze.
These data support an interaction between copper/cholesterol and both Aβ and APP and further highlight the potential role of metal ion dyshomeostasis in AD.
American Psychological Association (APA)
Manso, Yasmina& Comes, Gemma& Hidalgo, Juan& Bush, Ashley I.& Adlard, Paul A.. 2011. Copper Modulation as a Therapy for Alzheimer's Disease?. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-466645
Modern Language Association (MLA)
Manso, Yasmina…[et al.]. Copper Modulation as a Therapy for Alzheimer's Disease?. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-466645
American Medical Association (AMA)
Manso, Yasmina& Comes, Gemma& Hidalgo, Juan& Bush, Ashley I.& Adlard, Paul A.. Copper Modulation as a Therapy for Alzheimer's Disease?. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-466645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466645