Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer : A Single-Institutional Analysis in Saudi Arabia
Joint Authors
Ahmad Nour, Alaa
Rudat, Volker
Masri, Nidal
Altuwaijri, Saleh
Brune-Erber, Iris
Bushnag, Zinaida
El-Sweilmeen, Hamdan
Fadel, Elias
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
This study was undertaken to evaluate the impact of prognostic factors on the locoregional failure-free survival of early breast cancer patients.
Methods.
In this single-institutional study, 213 breast cancer patients were retrospectively analysed.
Fifty-five of 213 patients were ≤40 years of age at diagnosis.
The impact of patient- or treatment-related factors on the locoregional failure-free survival was assessed using the Kaplan-Meier method.
The simultaneous impact of factors on the locoregional failure-free survival was assessed using the Cox proportional hazards regression analysis.
Results.
The median follow-up time of the censored patients was 22 months (mean 28 months, range 3–92 months).
On univariate analysis, statistically significant factors for the locoregional failure-free survival were the age (≤40 versus >40 years), T stage (Tis, T0–2 versus T3-4), molecular tumor type (luminal A versus luminal B, Her2neu overexpression, or triple negative), and lymphovascular status (LV0 versus LV1).
On multivariate analysis, age and T stage remained statistically significant.
Conclusions.
Being 40 years or younger has a statistically significant independent adverse impact on the locoregional failure-free survival of patients with early breast cancer.
American Psychological Association (APA)
Rudat, Volker& El-Sweilmeen, Hamdan& Fadel, Elias& Brune-Erber, Iris& Ahmad Nour, Alaa& Bushnag, Zinaida…[et al.]. 2012. Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer : A Single-Institutional Analysis in Saudi Arabia. Journal of Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466652
Modern Language Association (MLA)
Rudat, Volker…[et al.]. Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer : A Single-Institutional Analysis in Saudi Arabia. Journal of Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-466652
American Medical Association (AMA)
Rudat, Volker& El-Sweilmeen, Hamdan& Fadel, Elias& Brune-Erber, Iris& Ahmad Nour, Alaa& Bushnag, Zinaida…[et al.]. Age of 40 Years or Younger Is an Independent Risk Factor for Locoregional Failure in Early Breast Cancer : A Single-Institutional Analysis in Saudi Arabia. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466652