DNA Repair and Cancer Therapy : Targeting APE1Ref-1 Using Dietary Agents
Joint Authors
Raffoul, Julian J.
Heydari, Ahmad R.
Hillman, Gilda G.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Epidemiological studies have demonstrated the cancer protective effects of dietary agents and other natural compounds isolated from fruits, soybeans, and vegetables on neoplasia.
Studies have also revealed the potential for these natural products to be combined with chemotherapy or radiotherapy for the more effective treatment of cancer.
In this paper we discuss the potential for targeting the DNA base excision repair enzyme APE1/Ref-1 using dietary agents such as soy isoflavones, resveratrol, curcumin, and the vitamins ascorbate and α-tocopherol.
We also discuss the potential role of soy isoflavones in sensitizing cancer cells to the effects of radiotherapy.
A comprehensive review of the dual nature of APE1/Ref-1 in DNA repair and redox activation of cellular transcription factors, NF-κB and HIF-1α, is also discussed.
Further research efforts dedicated to delineating the role of APE1/Ref-1 DNA repair versus redox activity in sensitizing cancer cells to conventional treatment are warranted.
American Psychological Association (APA)
Raffoul, Julian J.& Heydari, Ahmad R.& Hillman, Gilda G.. 2012. DNA Repair and Cancer Therapy : Targeting APE1Ref-1 Using Dietary Agents. Journal of Oncology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-466660
Modern Language Association (MLA)
Raffoul, Julian J.…[et al.]. DNA Repair and Cancer Therapy : Targeting APE1Ref-1 Using Dietary Agents. Journal of Oncology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-466660
American Medical Association (AMA)
Raffoul, Julian J.& Heydari, Ahmad R.& Hillman, Gilda G.. DNA Repair and Cancer Therapy : Targeting APE1Ref-1 Using Dietary Agents. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-466660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466660