Association of Influenza Virus Proteins with Membrane Rafts
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-25
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Assembly and budding of influenza virus proceeds in the viral budozone, a domain in the plasma membrane with characteristics of cholesterol/sphingolipid-rich membrane rafts.
The viral transmembrane glycoproteins hemagglutinin (HA) and neuraminidase (NA) are intrinsically targeted to these domains, while M2 is seemingly targeted to the edge of the budozone.
Virus assembly is orchestrated by the matrix protein M1, binding to all viral components and the membrane.
Budding progresses by protein- and lipid-mediated membrane bending and particle scission probably mediated by M2.
Here, we summarize the experimental evidence for this model with emphasis on the raft-targeting features of HA, NA, and M2 and review the functional importance of raft domains for viral protein transport, assembly and budding, environmental stability, and membrane fusion.
American Psychological Association (APA)
Veit, Michael& Thaa, Bastian. 2011. Association of Influenza Virus Proteins with Membrane Rafts. Advances in Virology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-466675
Modern Language Association (MLA)
Veit, Michael& Thaa, Bastian. Association of Influenza Virus Proteins with Membrane Rafts. Advances in Virology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-466675
American Medical Association (AMA)
Veit, Michael& Thaa, Bastian. Association of Influenza Virus Proteins with Membrane Rafts. Advances in Virology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-466675
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466675