Update on the Pathophysiological Activities of the Cardiac Molecule Cardiotrophin-1 in Obesity
Joint Authors
Dallegri, Franco
Quercioli, Alessandra
Montecucco, Fabrizio
Mach, François
Asrih, Mohamed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiotrophin-1 (CT-1) is a heart-targeting cytokine that has been reported to exert a variety of activities also in other organs such as the liver, adipose tissue, and atherosclerotic arteries.
CT-1 has been shown to induce these effects via binding to a transmembrane receptor, comprising the leukaemia inhibitory factor receptor (LIFRβ) subunit and the glycoprotein 130 (gp130, a common signal transducer).
Both local and systemic concentrations of CT-1 have been shown to potentially play a critical role in obesity.
For instance, CT-1 plasma concentrations have been shown to be increased in metabolic syndrome (a cluster disease including obesity) probably due to adipose tissue overexpression.
Interestingly, treatment with exogenous CT-1 has been shown to improve lipid and glucose metabolism in animal models of obesity.
These benefits might suggest a potential therapeutic role for CT-1.
However, beyond its beneficial properties, CT-1 has been also shown to induce some adverse effects, such as cardiac hypertrophy and adipose tissue inflammation.
Although scientific evidence is still needed, CT-1 might be considered as a potential example of damage/danger-associated molecular pattern (DAMP) in obesity-related cardiovascular diseases.
In this narrative review, we aimed at discussing and updating evidence from basic research on the pathophysiological and potential therapeutic roles of CT-1 in obesity.
American Psychological Association (APA)
Asrih, Mohamed& Mach, François& Quercioli, Alessandra& Dallegri, Franco& Montecucco, Fabrizio. 2013. Update on the Pathophysiological Activities of the Cardiac Molecule Cardiotrophin-1 in Obesity. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-466688
Modern Language Association (MLA)
Asrih, Mohamed…[et al.]. Update on the Pathophysiological Activities of the Cardiac Molecule Cardiotrophin-1 in Obesity. Mediators of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-466688
American Medical Association (AMA)
Asrih, Mohamed& Mach, François& Quercioli, Alessandra& Dallegri, Franco& Montecucco, Fabrizio. Update on the Pathophysiological Activities of the Cardiac Molecule Cardiotrophin-1 in Obesity. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-466688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466688