Structural Features of the Peptide Homologous to 6-25 Fragment of Influenza A PB1 Protein
Joint Authors
Matusevich, Oleg V.
Egorov, Vladimir V.
Vasin, Andrey V.
Shaldzhyan, Aram A.
Zabrodskaya, Yana A.
Sirotkin, Alexey K.
Kiselev, Oleg I.
Lebedev, Dmitry V.
Zarubayev, Vladimir V.
Garmay, Yuri P.
Landa, Sergey B.
Skvortsov, Alexey N.
Source
International Journal of Peptides
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-24
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A mirror-symmetry motif was discovered in the N-terminus of the influenza virus PB1 protein.
Structure of peptide comprised of the corresponding part of PB1 (amino acid residues 6-25) was investigated by circular dichroism and in silico modeling.
We found that peptide PB1 (6-25) in solution assumes beta-hairpin conformation.
A truncated peptide PB1 (6-13), containing only half of the mirror-symmetry motif, appeared to stabilize the beta-structure of the original peptide and, at high concentrations, was capable of reacting with peptide to form insoluble aggregates in vitro.
Ability of PB1 (6-13) peptide to interact with the N-terminal domain of PB1 protein makes it a potential antiviral agent that inhibits PA-PB1 complex formation by affecting PB1 N-terminus structure.
American Psychological Association (APA)
Egorov, Vladimir V.& Matusevich, Oleg V.& Shaldzhyan, Aram A.& Skvortsov, Alexey N.& Zabrodskaya, Yana A.& Garmay, Yuri P.…[et al.]. 2013. Structural Features of the Peptide Homologous to 6-25 Fragment of Influenza A PB1 Protein. International Journal of Peptides،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466700
Modern Language Association (MLA)
Egorov, Vladimir V.…[et al.]. Structural Features of the Peptide Homologous to 6-25 Fragment of Influenza A PB1 Protein. International Journal of Peptides No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-466700
American Medical Association (AMA)
Egorov, Vladimir V.& Matusevich, Oleg V.& Shaldzhyan, Aram A.& Skvortsov, Alexey N.& Zabrodskaya, Yana A.& Garmay, Yuri P.…[et al.]. Structural Features of the Peptide Homologous to 6-25 Fragment of Influenza A PB1 Protein. International Journal of Peptides. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466700