1H MR Spectroscopy in Gliomatosis : Is there a Sensitivity Issue?

Abstract EN

Objective.

1H MR spectroscopy (MRS) is widely performed for assessment of brain tumours and is considered a highly sensitive technique capable of differentiating benign from malignant conditions and tumour grading.

Method.

We present a case of a 69 year old woman who was suspected to have gliomatosis on MRI.

Results.

MRS performed using single voxel and chemical shift/multivoxel techniques was within normal limits.

A repeat scan 6 months later showed progressive disease, and biopsy was performed that proved the diagnosis of glioblastoma.

Conclusion.

Normal MRS in a patient with suspicion of gliomatosis on MRI should not reassure clinicians into assuming a benign aetiology or a good prognosis in short term.