Adipokines Do Not Mediate the Association of Obesity and Colorectal Adenoma

Joint Authors

Chen, Zhengyi
Thompson, Cheryl L.
Freudenheim, Jo L.
Li, Li
Tracy, Russell
Millen, Amy E.
Cannioto, Rikki
Nie, Jing
Ochs-Balcom, Heather M.

Source

Journal of Cancer Epidemiology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-08-13

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Diseases
Medicine

Abstract EN

Purpose.

The association between obesity and colon neoplasia is well established but the underlying biological mechanisms are not fully understood.

Rates of both obesity and colon cancer differ by race.

Adipokines have been postulated as contributors to the observed association; however, few studies have examined the mediating effect of adipokines on the obesity-colon adenoma association with consideration of racial differences.

Methods.

We determined prediagnostic levels of adiponectin and leptin in Caucasians (217 cases and 650 controls) and African Americans (175 cases and 378 controls) participating in the Case Transdisciplinary Research on Energetics and Cancer Colon Adenoma Study.

We evaluated mediating effects of adiponectin and leptin on the association of abdominal adiposity and colon adenoma separately according to race using mediational pathway analysis.

Results.

We observed differences in circulating adipokine concentrations by race; African Americans had higher levels of leptin and lower levels of adiponectin than Caucasians for both adenoma cases and controls (P values <0.001).

Leptin and adiponectin did not mediate the waist-to-hip ratio (WHR) adenoma association in either group (all Sobel P values >0.27).

Conclusions.

We found no evidence that leptin or adiponectin mediates the abdominal obesity-colorectal adenoma pathway.

Larger studies on how these associations vary by race, sex, and obesity are needed.

American Psychological Association (APA)

Ochs-Balcom, Heather M.& Cannioto, Rikki& Nie, Jing& Millen, Amy E.& Freudenheim, Jo L.& Chen, Zhengyi…[et al.]. 2014. Adipokines Do Not Mediate the Association of Obesity and Colorectal Adenoma. Journal of Cancer Epidemiology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-466739

Modern Language Association (MLA)

Ochs-Balcom, Heather M.…[et al.]. Adipokines Do Not Mediate the Association of Obesity and Colorectal Adenoma. Journal of Cancer Epidemiology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-466739

American Medical Association (AMA)

Ochs-Balcom, Heather M.& Cannioto, Rikki& Nie, Jing& Millen, Amy E.& Freudenheim, Jo L.& Chen, Zhengyi…[et al.]. Adipokines Do Not Mediate the Association of Obesity and Colorectal Adenoma. Journal of Cancer Epidemiology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-466739

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-466739