Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors
Joint Authors
Chung, Suk-won
Ko, Kevin
Ahn, Saeyoung Nate
Kwon, Hena H.
Stefansson, Lára A.
Stefansson, Steingrimur
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Abstract EN
Biomolecular detections performed on carbon nanotube field-effect transistors (CNT-FETs) frequently use reactive pyrenes as an anchor to tether bioactive ligands to the hydrophobic nanotubes.
In this paper, we explore the possibility of directly using bioactive aromatic compounds themselves as CNT-FET ligands.
This would be an efficient way to functionalize CNT-FETs since many aromatic compounds bind avidly to nanotubes, and it would also ensure that ligand-binding molecules would be brought in close proximity to the nanotubes.
Using a model system consisting of pyrene, phenanthrene, naphthalene, or phenyl boronic acids immobilized on CNT-FET wafers, we show that all are able to bind glycated human serum albumin (gHSA), which is an important diabetes marker.
Pyrene boronic acid proved to bind CNTs with the greatest apparent affinity as measured by gHSA impedance.
Interestingly, gHSA CNT-FET signal intensity, which is proportional to amount of protein bound, remained essentially unchanged for all the boronic acids tested.
American Psychological Association (APA)
Stefansson, Steingrimur& Stefansson, Lára A.& Chung, Suk-won& Ko, Kevin& Kwon, Hena H.& Ahn, Saeyoung Nate. 2012. Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors. Journal of Nanotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-466761
Modern Language Association (MLA)
Stefansson, Steingrimur…[et al.]. Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors. Journal of Nanotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-466761
American Medical Association (AMA)
Stefansson, Steingrimur& Stefansson, Lára A.& Chung, Suk-won& Ko, Kevin& Kwon, Hena H.& Ahn, Saeyoung Nate. Evaluation of Aromatic Boronic Acids as Ligands for Measuring Diabetes Markers on Carbon Nanotube Field-Effect Transistors. Journal of Nanotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-466761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466761