![](/images/graphics-bg.png)
Alcohol Induced Mitochondrial Oxidative Stress and Alveolar Macrophage Dysfunction
Joint Authors
Harris, Frank L.
Brown, Lou Ann S.
Liang, Yan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
An alcohol use disorder increases the risk of invasive and antimicrobial resistant community-acquired pneumonia and tuberculosis.
Since the alveolar macrophage (AM) orchestrates the immune response in the alveolar space, understanding the underlying mechanisms by which alcohol suppresses AM phagocytosis is critical to improving clinical outcomes.
In the alveolar space, chronic alcohol ingestion causes severe oxidative stress and depletes antioxidants which are critical for AM function.
The mitochondrion is important in maintaining cellular redox balance and providing the ATP critical for phagocytosis.
The focus of this study was to understand how alcohol triggers mitochondrial reactive oxygen species (ROS), stimulates cellular oxidative stress, and induces AM dysfunction.
The current study also investigated the capacity of the mitochondrial targeted antioxidant, mitoTEMPOL (mitoT), in modulating mitochondrial oxidative stress, and AM dysfunction.
Using in vitro ethanol exposure and AMs from ethanol-fed mice, ethanol promoted mitochondrial dysfunction including increased mitochondrial ROS, decreased mitochondrial membrane potential, and decreased ATP.
Treatment with mitoT reversed these effects.
Ethanol-induced decreases in phagocytosis and cell viability were also attenuated with mitoT.
Therefore, antioxidants targeted to the mitochondria have the potential to ameliorate ethanol-induced mitochondrial oxidative stress and subsequent decreases in AM phagocytosis and cell viability.
American Psychological Association (APA)
Liang, Yan& Harris, Frank L.& Brown, Lou Ann S.. 2014. Alcohol Induced Mitochondrial Oxidative Stress and Alveolar Macrophage Dysfunction. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-466774
Modern Language Association (MLA)
Liang, Yan…[et al.]. Alcohol Induced Mitochondrial Oxidative Stress and Alveolar Macrophage Dysfunction. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-466774
American Medical Association (AMA)
Liang, Yan& Harris, Frank L.& Brown, Lou Ann S.. Alcohol Induced Mitochondrial Oxidative Stress and Alveolar Macrophage Dysfunction. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-466774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466774