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Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide : Pharmacological Concerns of Side Effects
Joint Authors
Reuter, H.
Dohmen, C.
Müller, C.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Quetiapine is an atypical antipsychotic approved for the treatment of patients with psychotic disorders.
Since approvement several case reports about intoxication with quetiapine were linked mainly with tachycardia, QTc-prolongation, somnolence, and hyperglycemia.
Here, we present the first case report of an intoxication with an extreme overdose of quetiapine (36 g), ingested by a 32-year-old female (62 kg bodyweight) to attempt suicide.
Symptoms associated with intoxication were coma without arterial hypotension, persistent tachycardia, hyperglycemia, and transient hypothyreoidism.
QTc-interval was moderately extended.
Management consisted of intubation for airway protection, gastric lavage, the use of activated charcoal, i.v.
saline, and observation for 17 hours on an intensive care unit.
Despite the extremely high dose of quetiapine, the patient recovered completely without residual symptoms.
American Psychological Association (APA)
Müller, C.& Reuter, H.& Dohmen, C.. 2010. Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide : Pharmacological Concerns of Side Effects. Case Reports in Medicine،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-466784
Modern Language Association (MLA)
Müller, C.…[et al.]. Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide : Pharmacological Concerns of Side Effects. Case Reports in Medicine No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-466784
American Medical Association (AMA)
Müller, C.& Reuter, H.& Dohmen, C.. Intoxication after Extreme Oral Overdose of Quetiapine to Attempt Suicide : Pharmacological Concerns of Side Effects. Case Reports in Medicine. 2010. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-466784
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466784