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Feeding Regulates the Expression of Pancreatic Genes in Gastric Mucosa
Joint Authors
Yoshioka, Mayumi
De Giorgio, Maria Rita
St-Amand, Jonny
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The ineffective short-term control of feeding behavior compromises energy homeostasis and can lead to obesity.
The gastrointestinal tract secretes several regulatory peptides.
However, little is known about the stomach peptide contribution to the acute regulation of intake.
In an attempt to identify new gastric signals, the serial analysis of gene expression (SAGE) method was used for the transcription profiling of stomach mucosa in 7 groups of mice: fasting and sacrificed 30 minutes, 1 hour, 3 hours after a low-fat (LF) or high-fat (HF) ad libitum meal.
In total, 35 genes were differentially modulated by LF and HF meals compared to fasting, including 15 mRNAs coding for digestive enzymes/secretory proteins, and 10 novel transcripts.
Although the basic expression profile did not undergo substantial variations, both LF and HF meals influenced the transcription.
This study represents the first global analysis of stomach transcriptome as induced by different nutritional stimuli.
Further studies including the characterization of novel genes may help to identify new targets for the therapy and prevention of obesity.
American Psychological Association (APA)
De Giorgio, Maria Rita& Yoshioka, Mayumi& St-Amand, Jonny. 2010. Feeding Regulates the Expression of Pancreatic Genes in Gastric Mucosa. Journal of Obesity،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466815
Modern Language Association (MLA)
De Giorgio, Maria Rita…[et al.]. Feeding Regulates the Expression of Pancreatic Genes in Gastric Mucosa. Journal of Obesity No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-466815
American Medical Association (AMA)
De Giorgio, Maria Rita& Yoshioka, Mayumi& St-Amand, Jonny. Feeding Regulates the Expression of Pancreatic Genes in Gastric Mucosa. Journal of Obesity. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466815