Nephrotic Syndrome in Children : From Bench to Treatment
Joint Authors
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Idiopathic nephrotic syndrome (INS) is the most frequent form of NS in children.
INS is defined by the association of the clinical features of NS with renal biopsy findings of minimal changes, focal segmental glomerulosclerosis (FSGS), or mesangial proliferation (MP) on light microscopy and effacement of foot processes on electron microscopy.
Actually the podocyte has become the favourite candidate for constituting the main part of the glomerular filtration barrier.
Most cases are steroid sensitive (SSINS).
Fifty percents of the latter recur frequently and necessitate a prevention of relapses by nonsteroid drugs.
On the contrary to SSINS, steroid resistant nephrotic syndrome (SRINS) leads often to end-stage renal failure.
Thirty to forty percents of the latter are associated with mutations of genes coding for podocyte proteins.
The rest is due to one or several different circulating factors.
New strategies are in development to antagonize the effect of the latter.
American Psychological Association (APA)
Davin, J.-C.& Rutjes, N. W.. 2011. Nephrotic Syndrome in Children : From Bench to Treatment. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-466836
Modern Language Association (MLA)
Davin, J.-C.& Rutjes, N. W.. Nephrotic Syndrome in Children : From Bench to Treatment. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-466836
American Medical Association (AMA)
Davin, J.-C.& Rutjes, N. W.. Nephrotic Syndrome in Children : From Bench to Treatment. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-466836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466836