Rare Giant Granular Cell Ameloblastoma : A Case Report and an Immunohistochemical Study
Joint Authors
Koneru, Anila
Guruprasad, Yadavalli
Hunasgi, Santosh
Chauhan, Dinesh Singh
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
The aim is to present a case of rare giant granular cell ameloblastoma and to review the pertinent literature highlighting the molecular aspects of its pathogenesis by analyzing the expression of CD-68, Bcl-2, and β-catenin.
Methods.
H and E stained sections showed large odontogenic islands showing peripheral ameloblast-like cells and central stellate reticulum-like cells with extensive granular cell transformation surrounded by fibrous stroma.
Polyclonal rabbit anti-CD 68, anti-Bcl2, and anti-β-catenin were stained immunohistochemically.
Results.
CD-68 showed a moderate to strong staining intensity in granular cells.
Moderate staining of Bcl-2 was expressed by the peripheral columnar cells of tumor islands and negative in the granular cells.
Expression of β-catenin was generally weak, except for only the focal areas that showed a moderate staining intensity and weak in peripheral cells.
Conclusion.
The present case of giant granular cell ameloblastoma is a rare entity.
Development of monstrous size is indicative of ameloblastomas persistent growth.
Granular cell transformation in ameloblastomas probably occurs as a consequence of extensive molecular changes.
Immunohistochemical studies help us to know the pathogenesis of this granular cell ameloblastoma.
Therefore, an effort has been made here to study the expression of Bcl-2, CD-68, and β-catenin.
American Psychological Association (APA)
Hunasgi, Santosh& Koneru, Anila& Chauhan, Dinesh Singh& Guruprasad, Yadavalli. 2013. Rare Giant Granular Cell Ameloblastoma : A Case Report and an Immunohistochemical Study. Case Reports in Dentistry،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466882
Modern Language Association (MLA)
Hunasgi, Santosh…[et al.]. Rare Giant Granular Cell Ameloblastoma : A Case Report and an Immunohistochemical Study. Case Reports in Dentistry No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-466882
American Medical Association (AMA)
Hunasgi, Santosh& Koneru, Anila& Chauhan, Dinesh Singh& Guruprasad, Yadavalli. Rare Giant Granular Cell Ameloblastoma : A Case Report and an Immunohistochemical Study. Case Reports in Dentistry. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466882