In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice
Joint Authors
Carapau, Daniel
Frita, Rosangela
Hänscheid, Thomas
Mota, Maria M.
Source
Malaria Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hemozoin (Hz) is released into the blood stream after rupture of infected red blood cells (iRBCs) at the end of each parasite replication cycle.
This free Hz is ingested by circulating and resident phagocytes.
The presence of Hz in tissues after clearance of infection has been previously reported.
Still, little is known about the kinetics of Hz in vivo, during and after Plasmodium infection.
It is particularly important to understand Hz kinetics after malaria infections as it has been reported that Hz is associated with impairment of immune functions, including possible consequences for coinfections.
Indeed, if Hz remains biologically active for prolonged periods of time inside immunocompetent cells, the potential consequences of such accumulation and presence to the immune system should be clarified.
Here, using several independent methods to assess the presence of Hz, we report the long-term in vivo kinetics of Hz in diverse organs in a murine model of malaria infection.
American Psychological Association (APA)
Frita, Rosangela& Carapau, Daniel& Mota, Maria M.& Hänscheid, Thomas. 2012. In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice. Malaria Research and Treatment،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-466904
Modern Language Association (MLA)
Frita, Rosangela…[et al.]. In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice. Malaria Research and Treatment No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-466904
American Medical Association (AMA)
Frita, Rosangela& Carapau, Daniel& Mota, Maria M.& Hänscheid, Thomas. In Vivo Hemozoin Kinetics after Clearance of Plasmodium berghei Infection in Mice. Malaria Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-466904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466904