Simple Methods for the Spectrophotometric Determination of Carvedilol
Joint Authors
Narayana, Badiadka
Shetty, Divya N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Two simple spectrophotometric methods are described for the determination of carvedilol (CAR).
Method A is the condensation reaction of CAR with p-dimethylaminobenzaldehyde (PDAB), and the reaction mixture exhibits maximum absorbance at 601 nm.
Method B is based on the charge transfer complex formation of CAR with p-chloranil; the color developed is measured at 662 nm.
The calibration graphs are found to be linear over 50.00–250.00 and 20.00–100.0 μg mL−1 with molar absorptivity values of 0.92×103 and 0.257×104 L mol−1cm−1 for CAR-PDAB and CAR-p-chloranil, respectively.
Statistical comparisons of the results are performed with regard to accuracy and precision using Student’s t-test and F-test at 95% confidence level.
The methods are successfully employed for the determination of CAR in pharmaceutical preparations, and the results agree favorably with the reference and proposed methods.
American Psychological Association (APA)
Shetty, Divya N.& Narayana, Badiadka. 2012. Simple Methods for the Spectrophotometric Determination of Carvedilol. ISRN Spectroscopy،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-466912
Modern Language Association (MLA)
Shetty, Divya N.& Narayana, Badiadka. Simple Methods for the Spectrophotometric Determination of Carvedilol. ISRN Spectroscopy No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-466912
American Medical Association (AMA)
Shetty, Divya N.& Narayana, Badiadka. Simple Methods for the Spectrophotometric Determination of Carvedilol. ISRN Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-466912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466912