![](/images/graphics-bg.png)
Troglitazone Reduces Glyoxalase I Protein Expression in Glioma and Potentiates the Effects of Chemotherapeutic Agents
Joint Authors
Li, Jie
Zhuang, Zhengping
Lonser, Russell
Lubensky, Irina A.
Helgager, Jeffrey
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Despite resistance of most gliomas to chemotherapy, approximately 2/3 of oligodendrogliomas show sensitivity to such agents.
This sensitivity has been associated with deletions on chromosome 1p alone or in combination with 19q.
Higher expression of the enzyme glyoxalase I has been found in oligodendrogliomas with chromosome 1p intact compared to those with a deletion.
Higher expression of this enzyme is also associated with tumor chemoresistance in other cancers.
The present study tested whether the drug troglitazone would make a glioma cell line more sensitive to chemotherapeutic agents.
This drug was chosen because it has been shown to decrease glyoxalase I enzyme activity in cells.
Treatment with troglitazone decreased expression of glyoxalase I, and potentiated cell death when used in combination with chemotherapeutic agents.
This decrease in glyoxalase I protein may be one mechanism by which this potentiation occurs, and troglitazone may be a candidate for use in glioma therapy.
American Psychological Association (APA)
Helgager, Jeffrey& Li, Jie& Lubensky, Irina A.& Lonser, Russell& Zhuang, Zhengping. 2010. Troglitazone Reduces Glyoxalase I Protein Expression in Glioma and Potentiates the Effects of Chemotherapeutic Agents. Journal of Oncology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-466929
Modern Language Association (MLA)
Helgager, Jeffrey…[et al.]. Troglitazone Reduces Glyoxalase I Protein Expression in Glioma and Potentiates the Effects of Chemotherapeutic Agents. Journal of Oncology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-466929
American Medical Association (AMA)
Helgager, Jeffrey& Li, Jie& Lubensky, Irina A.& Lonser, Russell& Zhuang, Zhengping. Troglitazone Reduces Glyoxalase I Protein Expression in Glioma and Potentiates the Effects of Chemotherapeutic Agents. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-466929
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466929