Cytotoxicity of Algae Extracts on Normal and Malignant Cells
Joint Authors
Coppage, M. L.
Bechelli, Jeremy
Liesveld, Jane
Rosell, Karen
Source
Leukemia Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Algae preparations are commonly used in alternative medicine.
We examined the effects of algae extracts on normal hematopoietic cells and leukemia cells.
Ethanol extracts were prepared of Dunaliella salina (Dun), Astaxanthin (Ast), Spirulina platensis (Spir), and Aphanizomenon flos-aquae (AFA).
Cell viability effects were completed by Annexin staining.
Ast and AFA inhibited HL-60 and MV-4-11 whereas Dun and Spir had no effect.
Primary AML blasts demonstrated increased apoptosis in AFA.
Primary CLL cells showed apoptosis at 24 hours after exposure to Dun, Ast, Spir, and AFA.
High AFA concentrations decreased viability of normal marrow cells.
Normal CD34+ viability was inhibited by Dun.
Dun and AFA inhibited BFU-E, but all extracts inhibited CFU-GM.
Cell-cycle analysis of AML cell lines showed G0/G1 arrest in the presence of AFA.
These data suggest that algae extracts may inhibit AML cell lines and leukemia blasts, but they may also have potential inhibitory effects on normal hematopoiesis.
American Psychological Association (APA)
Bechelli, Jeremy& Coppage, M. L.& Rosell, Karen& Liesveld, Jane. 2011. Cytotoxicity of Algae Extracts on Normal and Malignant Cells. Leukemia Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466932
Modern Language Association (MLA)
Bechelli, Jeremy…[et al.]. Cytotoxicity of Algae Extracts on Normal and Malignant Cells. Leukemia Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-466932
American Medical Association (AMA)
Bechelli, Jeremy& Coppage, M. L.& Rosell, Karen& Liesveld, Jane. Cytotoxicity of Algae Extracts on Normal and Malignant Cells. Leukemia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466932