The Effects of Erythropoietin Dose Titration during High-Fat Diet-Induced Obesity
Joint Authors
Foskett, Amanda
Noguchi, Constance Tom
Wang, Li
Teng, Ruifeng
Alnaeeli, Mawadda
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Erythropoietin (Epo) is a pleotropic cytokine with several nonhematopoietic tissue effects.
High-dose Epo treatment-mediated effects on body weight, fat mass and glucose tolerance have recently been reported, thus extending its pleotropic effects to fat and glucose metabolism.
However, the exact dose range of Epo treatment required for such effects remains unidentified to date.
We investigated Epo dosage effect (up to 1000 U/kg) on hematocrit, body weight, body composition, glucose metabolism, food intake, and physical activity, during high-fat diet-induced obesity.
We report that Epo doses (1000, 600, 300, and 150 U/kg) significantly reduced body weight gain and fat mass, while, only Epo doses of 300 U/kg and higher significantly affected glucose tolerance.
None of the tested Epo doses showed any detectable effects on food intake, and only 1000 U/kg dose significantly increased physical activity, suggesting that these parameters may only be partially responsible for the metabolic effects of Epo treatment.
American Psychological Association (APA)
Foskett, Amanda& Alnaeeli, Mawadda& Wang, Li& Teng, Ruifeng& Noguchi, Constance Tom. 2011. The Effects of Erythropoietin Dose Titration during High-Fat Diet-Induced Obesity. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-466954
Modern Language Association (MLA)
Foskett, Amanda…[et al.]. The Effects of Erythropoietin Dose Titration during High-Fat Diet-Induced Obesity. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-466954
American Medical Association (AMA)
Foskett, Amanda& Alnaeeli, Mawadda& Wang, Li& Teng, Ruifeng& Noguchi, Constance Tom. The Effects of Erythropoietin Dose Titration during High-Fat Diet-Induced Obesity. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-466954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466954