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Phosphorylation : The Molecular Switch of Double-Strand Break Repair
Joint Authors
Sierra Potchanant, E. A.
Hickey, R. J.
Shen, F.
Phipps, E. A.
Summers, K. C.
Malkas, L. H.
Source
International Journal of Proteomics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Repair of double-stranded breaks (DSBs) is vital to maintaining genomic stability.
In mammalian cells, DSBs are resolved in one of the following complex repair pathways: nonhomologous end-joining (NHEJ), homologous recombination (HR), or the inclusive DNA damage response (DDR).
These repair pathways rely on factors that utilize reversible phosphorylation of proteins as molecular switches to regulate DNA repair.
Many of these molecular switches overlap and play key roles in multiple pathways.
For example, the NHEJ pathway and the DDR both utilize DNA-PK phosphorylation, whereas the HR pathway mediates repair with phosphorylation of RPA2, BRCA1, and BRCA2.
Also, the DDR pathway utilizes the kinases ATM and ATR, as well as the phosphorylation of H2AX and MDC1.
Together, these molecular switches regulate repair of DSBs by aiding in DSB recognition, pathway initiation, recruitment of repair factors, and the maintenance of repair mechanisms.
American Psychological Association (APA)
Summers, K. C.& Shen, F.& Sierra Potchanant, E. A.& Phipps, E. A.& Hickey, R. J.& Malkas, L. H.. 2011. Phosphorylation : The Molecular Switch of Double-Strand Break Repair. International Journal of Proteomics،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-466961
Modern Language Association (MLA)
Summers, K. C.…[et al.]. Phosphorylation : The Molecular Switch of Double-Strand Break Repair. International Journal of Proteomics No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-466961
American Medical Association (AMA)
Summers, K. C.& Shen, F.& Sierra Potchanant, E. A.& Phipps, E. A.& Hickey, R. J.& Malkas, L. H.. Phosphorylation : The Molecular Switch of Double-Strand Break Repair. International Journal of Proteomics. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-466961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466961