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Possible Therapeutic Use of Spermatogonial Stem Cells in the Treatment of Male Infertility : A Brief Overview
Joint Authors
Čukuranović, Rade
Stefanovic, Vladisav
Vlajković, Slobodan
Daković Bjelaković, Marija
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Development of germ cells is a process starting in fetus and completed only in puberty.
Spermatogonial stem cells maintain spermatogenesis throughout the reproductive life of mammals.
They are undifferentiated cells defined by their ability to both self-renew and differentiate into mature spermatozoa.
This self-renewal and differentiation in turn is tightly regulated by a combination of intrinsic gene expression as well as the extrinsic gene signals from the local tissue microenvironment.
The human testis is prone to damage, either for therapeutic reasons or because of toxic agents from the environment.
For preservation of fertility, patients who will undergo radiotherapy and/or chemotherapy have an attractive possibility to keep in store and afterwards make a transfer of spermatogonial stem cells.
Germ cell transplantation is not yet ready for the human fertility clinic, but it may be reasonable for young cancer patients, with no other options to preserve their fertility.
Whereas this technique has become an important research tool in rodents, a clinical application must still be regarded as experimental, and many aspects of the procedure need to be optimized prior to a clinical application in men.
In future, a range of options for the preservation of male fertility will get a new significance.
American Psychological Association (APA)
Vlajković, Slobodan& Čukuranović, Rade& Daković Bjelaković, Marija& Stefanovic, Vladisav. 2012. Possible Therapeutic Use of Spermatogonial Stem Cells in the Treatment of Male Infertility : A Brief Overview. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467003
Modern Language Association (MLA)
Vlajković, Slobodan…[et al.]. Possible Therapeutic Use of Spermatogonial Stem Cells in the Treatment of Male Infertility : A Brief Overview. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-467003
American Medical Association (AMA)
Vlajković, Slobodan& Čukuranović, Rade& Daković Bjelaković, Marija& Stefanovic, Vladisav. Possible Therapeutic Use of Spermatogonial Stem Cells in the Treatment of Male Infertility : A Brief Overview. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467003
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467003