MR Imaging of Hepatocellular Adenomas and Differential Diagnosis Dilemma
Joint Authors
Grazioli, Luigi
Bondioni, Maria Pia
Mazza, Giancarlo
Olivetti, Lucio
Source
International Journal of Hepatology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Hepatocellular adenomas (HCAs) are currently categorized into distinct genetic and pathologic subtypes as follows: inflammatory hepatocellular adenoma, hepatocyte-nuclear-factor-1-alpha (HNF-1α-mutated) hepatocellular adenoma, and β-catenin-mutated hepatocellular adenomas; the fourth, defined as unclassified subtype, encompasses HCAs without any genetic abnormalities.
This classification has accepted management implications due to different risks of haemorrhage and malignant transformation of the four subtypes.
Imaging guided biopsy and/or surgical resection very important in obtaining definitive characterization; nevertheless, MRI with intra-extravascular and hepatobiliary (dual phase) agents, is an important tool not only in differential subtypes definition but even in surveillance with early identification of complications and discovery of some signs of HCA malignant degeneration.
Inflammation, abnormal rich vascularisation, peliotic areas, and abundant fatty infiltration are pathologic findings differently present in the HCA subtypes and they may be detected by multiparametric MRI approach.
Lesion enlargement and heterogeneity of signal intensity and of contrast enhancement are signs to be considered in malignant transformation.
The purpose of this paper is to present the state of the art of MRI in the diagnosis of HCA and subtype characterization, with particular regard to morphologic and functional information available with dual phase contrast agents, and to discuss differential diagnosis with the most common benign and malignant lesions mimicking HCAs.
American Psychological Association (APA)
Grazioli, Luigi& Olivetti, Lucio& Mazza, Giancarlo& Bondioni, Maria Pia. 2013. MR Imaging of Hepatocellular Adenomas and Differential Diagnosis Dilemma. International Journal of Hepatology،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-467007
Modern Language Association (MLA)
Grazioli, Luigi…[et al.]. MR Imaging of Hepatocellular Adenomas and Differential Diagnosis Dilemma. International Journal of Hepatology No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-467007
American Medical Association (AMA)
Grazioli, Luigi& Olivetti, Lucio& Mazza, Giancarlo& Bondioni, Maria Pia. MR Imaging of Hepatocellular Adenomas and Differential Diagnosis Dilemma. International Journal of Hepatology. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-467007
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467007