Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers
Joint Authors
Salmaso, Stefano
Caliceti, Paolo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Over the last few decades, nanocarriers for drug delivery have emerged as powerful tools with unquestionable potential to improve the therapeutic efficacy of anticancer drugs.
Many colloidal drug delivery systems are underdevelopment to ameliorate the site specificity of drug action and reduce the systemic side effects.
By virtue of their small size they can be injected intravenously and disposed into the target tissues where they release the drug.
Nanocarriers interact massively with the surrounding environment, namely, endothelium vessels as well as cells and blood proteins.
Consequently, they are rapidly removed from the circulation mostly by the mononuclear phagocyte system.
In order to endow nanosystems with long circulation properties, new technologies aimed at the surface modification of their physicochemical features have been developed.
In particular, stealth nanocarriers can be obtained by polymeric coating.
In this paper, the basic concept underlining the “stealth” properties of drug nanocarriers, the parameters influencing the polymer coating performance in terms of opsonins/macrophages interaction with the colloid surface, the most commonly used materials for the coating process and the outcomes of this peculiar procedure are thoroughly discussed.
American Psychological Association (APA)
Salmaso, Stefano& Caliceti, Paolo. 2013. Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-467015
Modern Language Association (MLA)
Salmaso, Stefano& Caliceti, Paolo. Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers. Journal of Drug Delivery No. 2013 (2013), pp.1-19.
https://search.emarefa.net/detail/BIM-467015
American Medical Association (AMA)
Salmaso, Stefano& Caliceti, Paolo. Stealth Properties to Improve Therapeutic Efficacy of Drug Nanocarriers. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-19.
https://search.emarefa.net/detail/BIM-467015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467015