Association Study of Genetic Variants in CDKN2ACDKN2B GenesLoci with Late-Onset Alzheimer's Disease
Joint Authors
Piaceri, Irene
Arendt, Thomas
Nacmias, Benedetta
Bagnoli, Silvia
Tedde, Andrea
Sorbi, Sandro
Lucenteforte, Ersilia
Ueberham, Uwe
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-14
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Alzheimer's disease (AD) is the most common form of dementia clinically characterized by progressive impairment of memory and other cognitive functions.
Many genetic researches in AD identified one common genetic variant (ε4) in Apolipoprotein E (APOE) gene as a risk factor for the disease.
Two independent genome-wide studies demonstrated a new locus on chromosome 9p21.3 implicated in Late-Onset Alzheimer's Disease (LOAD) susceptibility in Caucasians.
In the present study, we investigated the role of three SNP's in the CDKN2A gene (rs15515, rs3731246, and rs3731211) and one in the CDKN2B gene (rs598664) located in 9p21.3 using an association case-control study carried out in a group of Caucasian subjects including 238 LOAD cases and 250 controls.
The role of CDKN2A and CDKN2B genetic variants in AD is not confirmed in our LOAD patients, and further studies are needed to elucidate the role of these genes in the susceptibility of AD.
American Psychological Association (APA)
Tedde, Andrea& Piaceri, Irene& Bagnoli, Silvia& Lucenteforte, Ersilia& Ueberham, Uwe& Arendt, Thomas…[et al.]. 2011. Association Study of Genetic Variants in CDKN2ACDKN2B GenesLoci with Late-Onset Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-467041
Modern Language Association (MLA)
Tedde, Andrea…[et al.]. Association Study of Genetic Variants in CDKN2ACDKN2B GenesLoci with Late-Onset Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-467041
American Medical Association (AMA)
Tedde, Andrea& Piaceri, Irene& Bagnoli, Silvia& Lucenteforte, Ersilia& Ueberham, Uwe& Arendt, Thomas…[et al.]. Association Study of Genetic Variants in CDKN2ACDKN2B GenesLoci with Late-Onset Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-467041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467041