Effect of Selenium on HLA-DR Expression of Thyrocytes

Joint Authors

Kaczur, Viktória
Balázs, Csaba

Source

Autoimmune Diseases

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-02-02

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases

Abstract EN

Autoimmune thyroid diseases (ATDs) represent the most frequent forms of the organ-specific autoimmune thyroid disorders that result from interaction between genetic and environmental factors.

Selenium has been shown to exert a beneficial effect on the autoimmune thyroiditis.

In spite of therapeutical effect of selenium on autoimmunity, the mechanism of its action has not been revealed.

Objective.

To determine whether selenium in vitro thyrocytes cultures are able to influence the HLA-DR molecule expression of human thyrocytes and production of free oxygen radicals.

Method.

Thyrocytes were prepared from human thyroid gland and cultured in vitro in the presence of interferon-γ and sodium selenite.

The expression of HLA-DR molecules induced by interferon-γ in the presence of sodium selenite of various concentration was measured by fluorescence-activated cell sorter.

Results.

Selenium has a dose-dependent inhibitory effect on the expression of HLA-DR molecules of thyrocytes induced by interferon-γ.

This effect of selenium was in the inverse correlation with antioxidative capacity.

Conclusion.

Beneficial effect of selenium on autoimmune mechanism is a complex mechanism in which the inhibitory effect on HLA-DR molecule expression and antioxidative capacity are involved into therapy of autoimmune thyroiditis.

American Psychological Association (APA)

Balázs, Csaba& Kaczur, Viktória. 2012. Effect of Selenium on HLA-DR Expression of Thyrocytes. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-467042

Modern Language Association (MLA)

Balázs, Csaba& Kaczur, Viktória. Effect of Selenium on HLA-DR Expression of Thyrocytes. Autoimmune Diseases No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-467042

American Medical Association (AMA)

Balázs, Csaba& Kaczur, Viktória. Effect of Selenium on HLA-DR Expression of Thyrocytes. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-467042

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-467042