Effect of Selenium on HLA-DR Expression of Thyrocytes
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Autoimmune thyroid diseases (ATDs) represent the most frequent forms of the organ-specific autoimmune thyroid disorders that result from interaction between genetic and environmental factors.
Selenium has been shown to exert a beneficial effect on the autoimmune thyroiditis.
In spite of therapeutical effect of selenium on autoimmunity, the mechanism of its action has not been revealed.
Objective.
To determine whether selenium in vitro thyrocytes cultures are able to influence the HLA-DR molecule expression of human thyrocytes and production of free oxygen radicals.
Method.
Thyrocytes were prepared from human thyroid gland and cultured in vitro in the presence of interferon-γ and sodium selenite.
The expression of HLA-DR molecules induced by interferon-γ in the presence of sodium selenite of various concentration was measured by fluorescence-activated cell sorter.
Results.
Selenium has a dose-dependent inhibitory effect on the expression of HLA-DR molecules of thyrocytes induced by interferon-γ.
This effect of selenium was in the inverse correlation with antioxidative capacity.
Conclusion.
Beneficial effect of selenium on autoimmune mechanism is a complex mechanism in which the inhibitory effect on HLA-DR molecule expression and antioxidative capacity are involved into therapy of autoimmune thyroiditis.
American Psychological Association (APA)
Balázs, Csaba& Kaczur, Viktória. 2012. Effect of Selenium on HLA-DR Expression of Thyrocytes. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-467042
Modern Language Association (MLA)
Balázs, Csaba& Kaczur, Viktória. Effect of Selenium on HLA-DR Expression of Thyrocytes. Autoimmune Diseases No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-467042
American Medical Association (AMA)
Balázs, Csaba& Kaczur, Viktória. Effect of Selenium on HLA-DR Expression of Thyrocytes. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-467042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467042