Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
Joint Authors
Dymicka-Piekarska, Violetta
Kemona, Halina
Matowicka-Karna, Joanna
Source
Clinical and Developmental Immunology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
In the study performed in a group of patients infected with T.
gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-α).
The study objective was to assess the effect of T.
gondii on chosen indices of the immune response.
The study involved 52 women infected with T.
gondii (aged 18–42 years) prior to antiparasitic treatment.
In all the patients, we found IgM (index >0.7) and IgG which exceeded 300 IU/ml.
The control group (C) consisted of 40 healthy women aged 18–46 years.
In the study group (T) and in the control group (C), the levels of IgE, IL-5, IL-6, IL-10, IL-12, and TNF-α were determined.
In our study, T.
gondii patients had twofold higher levels of IL-5 and IL-6 as compared to healthy subjects, which seems to confirm the presence of an inflammatory state.
We found the level of IL-10 to be fivefold higher in the course of toxoplasmosis than in healthy controls.
The levels of IL-12 and TNF-α were comparable to those observed in healthy controls.
The study has revealed that that patients infected with T.
gondii show increased production of the humoral response cytokines, whereas the generation of the cell response cytokines remains unchanged.
American Psychological Association (APA)
Matowicka-Karna, Joanna& Dymicka-Piekarska, Violetta& Kemona, Halina. 2009. Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?. Clinical and Developmental Immunology،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-467050
Modern Language Association (MLA)
Matowicka-Karna, Joanna…[et al.]. Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?. Clinical and Developmental Immunology No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-467050
American Medical Association (AMA)
Matowicka-Karna, Joanna& Dymicka-Piekarska, Violetta& Kemona, Halina. Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?. Clinical and Developmental Immunology. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-467050
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467050