Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide
Joint Authors
Schroner, Zbynek
Tkáč, Ivan
Židzik, Jozef
Klimčáková, Lucia
Javorský, Martin
Štolfová, Mária
Šalagovič, Ján
Babjaková, Eva
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Previous studies showed associations between variants in TCF7L2 gene and the therapeutic response to sulfonylureas.
All sulfonylureas stimulate insulin secretion by the closure of ATP-sensitive potassium (KATP) channel.
The aim of the present study was to compare TCF7L2 genotype specific effect of gliclazide binding to KATP channel A-site (Group 1) with sulfonylureas binding to AB-site (Group 2).
A total of 101 patients were treated with sulfonylureas for 6 months as an add-on therapy to the previous metformin treatment.
TCF7L2 rs7903146 C/T genotype was identified by real-time PCR with subsequent melting curve analysis.
Analyses using the dominant genetic model showed significantly higher effect of gliclazide in the CC genotype group in comparison with combined CT + TT genotype group (1.32±0.15% versus 0.73±0.11%, Padj=0.005).
No significant difference in ΔHbA1c between the patients with CC genotype and the T-allele carriers was observed in Group 2.
In the multivariate analysis, only the TCF7L2 genotype (P=0.006) and the baseline HbA1c (P<0.001) were significant predictors of ΔHbA1c.
After introducing an interaction term between the TCF7L2 genotype and the sulfonylurea type into multivariate model, the interaction became a significant predictor (P=0.023) of ΔHbA1c.
The results indicate significantly higher difference in ΔHbA1c among the TCF7L2 genotypes in patients treated with gliclazide than in patients treated with glimepiride, glibenclamide, or glipizide.
American Psychological Association (APA)
Javorský, Martin& Babjaková, Eva& Klimčáková, Lucia& Schroner, Zbynek& Židzik, Jozef& Štolfová, Mária…[et al.]. 2013. Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-467068
Modern Language Association (MLA)
Javorský, Martin…[et al.]. Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide. International Journal of Endocrinology No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-467068
American Medical Association (AMA)
Javorský, Martin& Babjaková, Eva& Klimčáková, Lucia& Schroner, Zbynek& Židzik, Jozef& Štolfová, Mária…[et al.]. Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-467068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467068