Rhein Reduces Fat Weight in dbdb Mouse and Prevents Diet-Induced Obesity in C57Bl6 Mouse through the Inhibition of PPARγ Signaling
Joint Authors
Gu, Ming
Fan, Shengjie
Lu, Xiong
Hu, Na
Chu, Chunxiao
Huang, Cheng
Zhang, Yu
Li, Yiming
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Rheum palmatum has been used most frequently in the weight-reducing formulae in traditional Chinese medicine.
However, the components of Rheum palmatum that play the antiobesity role are still uncertain.
Here, we tested the weight-reducing effect of two major Rheum palmatum compounds on db/db mouse.
We found that rhein (100 mg kg−1 day−1), but not emodin, reduced the fat weight in db/db mouse.
Using diet-induced obese (DIO) C57BL/6 mice, we identified that rhein blocked high-fat diet-induced obesity, decreased fat mass and the size of white and brown adipocytes, and lowered serum cholesterol, LDL cholesterol, and fasting blood glucose levels in the mice.
To elucidate the underlying mechanisms, we used reporter assay and gene expression analysis and found that rhein inhibited peroxisome proliferator-activated receptor γ (PPARγ) transactivity and the expression of its target genes, suggesting that rhein may act as a PPARγ antagonist.
Our data indicate that rhein may be a promising choice for antiobesity therapy.
American Psychological Association (APA)
Zhang, Yu& Fan, Shengjie& Hu, Na& Gu, Ming& Chu, Chunxiao& Li, Yiming…[et al.]. 2012. Rhein Reduces Fat Weight in dbdb Mouse and Prevents Diet-Induced Obesity in C57Bl6 Mouse through the Inhibition of PPARγ Signaling. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467077
Modern Language Association (MLA)
Zhang, Yu…[et al.]. Rhein Reduces Fat Weight in dbdb Mouse and Prevents Diet-Induced Obesity in C57Bl6 Mouse through the Inhibition of PPARγ Signaling. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-467077
American Medical Association (AMA)
Zhang, Yu& Fan, Shengjie& Hu, Na& Gu, Ming& Chu, Chunxiao& Li, Yiming…[et al.]. Rhein Reduces Fat Weight in dbdb Mouse and Prevents Diet-Induced Obesity in C57Bl6 Mouse through the Inhibition of PPARγ Signaling. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467077