QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics
Joint Authors
Jørgensen, Hugo A.
Løberg, Else-Marie
Kroken, Rune A.
Aanesen, Kristina
Sriskandarajah, Sanjeevan
Johnsen, Erik
Source
Schizophrenia Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
QTc interval prolongation is a side effect of several antipsychotic drugs, with associated risks of torsade de pointes arrhythmias and sudden cardiac death.
There is an ongoing debate of whether or not electrocardiogram (ECG) assessments should be mandatory in patients starting antipsychotic drugs.
To investigate QTc prolongation in a clinically relevant patient group 171 adult patients acutely admitted to an emergency ward for psychosis were consecutively recruited.
ECGs were recorded at baseline and then at discharge or after 6 weeks at the latest (discharge/6 weeks), thus reflecting the acute phase treatment period.
The mean QTc interval was 421.1 (30.4) ms at baseline and there was a positive association between the QTc interval and the agitation score whereas the QTc interval was inversely associated with the serum calcium level.
A total of 11.6% had abnormally prolonged QTc intervals and another 14.3% had borderline prolongation.
At discharge/6 weeks, the corresponding proportions were reduced to 4.2% and 5.3%, respectively.
The reduction of the proportion with prolonged QTc intervals reached statistical significance (chi-square exact test: P=0.046).
The finding of about one-quarter of the patients with borderline or prolonged QTc intervals could indicate mandatory ECG recordings in this population.
This trial is registered with ClinicalTrials.gov ID: NCT00932529.
American Psychological Association (APA)
Johnsen, Erik& Aanesen, Kristina& Sriskandarajah, Sanjeevan& Kroken, Rune A.& Løberg, Else-Marie& Jørgensen, Hugo A.. 2013. QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics. Schizophrenia Research and Treatment،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-467090
Modern Language Association (MLA)
Johnsen, Erik…[et al.]. QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics. Schizophrenia Research and Treatment No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-467090
American Medical Association (AMA)
Johnsen, Erik& Aanesen, Kristina& Sriskandarajah, Sanjeevan& Kroken, Rune A.& Løberg, Else-Marie& Jørgensen, Hugo A.. QTc Prolongation in Patients Acutely Admitted to Hospital for Psychosis and Treated with Second Generation Antipsychotics. Schizophrenia Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-467090
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467090