Rare Manifestation of a Rare Disease, Acute Liver Failure in Adult Onset Still’s Disease : Dramatic Response to Methylprednisolone Pulse Therapy—A Case Report and Review
Joint Authors
Begum, Rehana
Tammana, Venkata S.
Sanderson, Andrew
Windham, Michael
Valluru, Nalini
Mekonen, Eyasu
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Adult onset Still’s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology.
It is characterized by daily fevers, arthralgias or arthritis, typical skin rash, and leukocytosis.
Hepatic involvement is frequently observed in the course of AOSD with mildly elevated transaminases and/or hepatomegaly.
Fulminant hepatic failure, occasionally requiring urgent liver transplantation, is a rare manifestation of AOSD.
Here, we present a case of 22-year-old woman with no significant medical history who initially came with fever, arthralgias, myalgias, generalized weakness, and sore throat.
Laboratory data showed mildly elevated transaminases and markedly elevated ferritin levels.
She was diagnosed with AOSD based on Yamaguchi diagnostic criteria and was started on prednisone.
Three months later, while she was on tapering dose of steroid, she presented with fever, abdominal pain, jaundice, and markedly elevated transaminases.
Extensive workup excluded all potential causes of liver failure.
She was diagnosed with AOSD associated acute liver failure (ALF).
Intravenous (IV) methylprednisolone pulse therapy was started, with dramatic improvement in liver function.
Our case demonstrated that ALF can present as a complication of AOSD and IV mega dose pulse methylprednisolone therapy can be employed as a first-line treatment in AOSD associated ALF with favorable outcome.
American Psychological Association (APA)
Valluru, Nalini& Tammana, Venkata S.& Windham, Michael& Mekonen, Eyasu& Begum, Rehana& Sanderson, Andrew. 2014. Rare Manifestation of a Rare Disease, Acute Liver Failure in Adult Onset Still’s Disease : Dramatic Response to Methylprednisolone Pulse Therapy—A Case Report and Review. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-467092
Modern Language Association (MLA)
Valluru, Nalini…[et al.]. Rare Manifestation of a Rare Disease, Acute Liver Failure in Adult Onset Still’s Disease : Dramatic Response to Methylprednisolone Pulse Therapy—A Case Report and Review. Case Reports in Medicine No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-467092
American Medical Association (AMA)
Valluru, Nalini& Tammana, Venkata S.& Windham, Michael& Mekonen, Eyasu& Begum, Rehana& Sanderson, Andrew. Rare Manifestation of a Rare Disease, Acute Liver Failure in Adult Onset Still’s Disease : Dramatic Response to Methylprednisolone Pulse Therapy—A Case Report and Review. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-467092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467092