How Hyperpolarization and the Recovery of Excitability Affect Propagation through a Virtual Anode in the Heart
Joint Authors
Roth, Bradley J.
Charteris, Nicholas P.
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Researchers have suggested that the fate of a shock-induced wave front at the edge of a “virtual anode” (a region hyperpolarized by the shock) is a key factor determining success or failure during defibrillation of the heart.
In this paper, we use a simple one-dimensional computer model to examine propagation speed through a hyperpolarized region.
Our goal is to test the hypothesis that rapid propagation through a virtual anode can cause failure of propagation at the edge of the virtual anode.
The calculations support this hypothesis and suggest that the time constant of the sodium inactivation gate is an important parameter.
These results may be significant in understanding the mechanism of the upper limit of vulnerability.
American Psychological Association (APA)
Charteris, Nicholas P.& Roth, Bradley J.. 2011. How Hyperpolarization and the Recovery of Excitability Affect Propagation through a Virtual Anode in the Heart. Computational and Mathematical Methods in Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-467095
Modern Language Association (MLA)
Charteris, Nicholas P.& Roth, Bradley J.. How Hyperpolarization and the Recovery of Excitability Affect Propagation through a Virtual Anode in the Heart. Computational and Mathematical Methods in Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-467095
American Medical Association (AMA)
Charteris, Nicholas P.& Roth, Bradley J.. How Hyperpolarization and the Recovery of Excitability Affect Propagation through a Virtual Anode in the Heart. Computational and Mathematical Methods in Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-467095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467095