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Correlation between Calcitonin Levels and [F18]FDG-PETCT in the Detection of Recurrence in Patients with Sporadic and Hereditary Medullary Thyroid Cancer
Joint Authors
Rondogianni, Phivi
Alevizaki, Maria
Skoura, Evangelia
Skilakaki, Maria
Tzanela, Marinella
Datseris, Ioannis E.
Tsagarakis, Stylianos
Exarhos, Dimitrios
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Measurement of serum calcitonin is important in the followup of patients with medullary thyroid carcinoma (MTC) and reliably reflects the presence of the disease.
This is the largest study so far in bibliography investigating the diagnostic accuracy of combined [18F]FDG-PET/CT in patients with MTC and elevated calcitonin levels.
Methods.
Between February 2007 and February 2011, 59 [18F]FDG-PET/CT were performed on 51 patients with MTC and elevated calcitonin levels for localization of recurrent disease.
Conventional morphologic imaging methods were negative or showed equivocal findings.
Results.
Among the 59 [18F]FDG-PET/CT, 29 were positive (26 had true-positive and 3 false-positive findings) and 30 negative.
The overall per-patient sensitivity of [18F]FDG-PET/CT was 44.1%.
Using as cut-off point the calcitonin value of 1000 pg/ml, in patients with calcitonin exceeding this value, sensitivity raised to 86.7%.
The overall sensitivity of [18F]FDG-PET/CT was lower (23%) in patients with MEN IIA syndrome.
Conclusion.
The findings of this paper show that [18F]FDG-PET/CT is valuable for the detection of recurrence in patients with highly elevated calcitonin levels, >1000 pg/mL, but in patients with lower calcitonin levels, its contribution is questionable.
Also, there is evidence that the sensitivity of [18F]FDG-PET/CT is lower in patients with MTC as part of MEN IIA syndrome.
American Psychological Association (APA)
Skoura, Evangelia& Datseris, Ioannis E.& Rondogianni, Phivi& Tsagarakis, Stylianos& Tzanela, Marinella& Skilakaki, Maria…[et al.]. 2012. Correlation between Calcitonin Levels and [F18]FDG-PETCT in the Detection of Recurrence in Patients with Sporadic and Hereditary Medullary Thyroid Cancer. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467111
Modern Language Association (MLA)
Skoura, Evangelia…[et al.]. Correlation between Calcitonin Levels and [F18]FDG-PETCT in the Detection of Recurrence in Patients with Sporadic and Hereditary Medullary Thyroid Cancer. ISRN Endocrinology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-467111
American Medical Association (AMA)
Skoura, Evangelia& Datseris, Ioannis E.& Rondogianni, Phivi& Tsagarakis, Stylianos& Tzanela, Marinella& Skilakaki, Maria…[et al.]. Correlation between Calcitonin Levels and [F18]FDG-PETCT in the Detection of Recurrence in Patients with Sporadic and Hereditary Medullary Thyroid Cancer. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-467111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467111