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Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice
Joint Authors
Sczepan, Teresa
Segelcke, Daniel
Mendritzki, Sonja
Lübbert, Hermann
Zhu, Xin-Ran
Schmidt, Saskia
Source
International Journal of Otolaryngology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Accumulation of α-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy.
In previous studies with transgenic C57BL/6 mice overexpressing α-synuclein carrying the mutations A53T and A30P found in Parkinson's disease or with a parkin-null background, we reported severe mitochondrial impairments in neurons and to a larger extent in glial cells of the mesencephalon.
Neuron death was not observed in the brain.
Here we show that the mice show severe motor impairments in behavioral tests.
In addition, these mice exhibit astrocytic cell death in the spinal cord, accompanied by extensive gliosis and microglial activation.
This is shown by cell death staining and immunohistochemistry.
Ultrastructural analyses revealed severe mitochondrial impairments not only in astrocytes, but also in oligodendrocytes and, to a small extent, in neurons.
Thus, the transgenic mice show a profound pathology in glial cells of the spinal cord.
American Psychological Association (APA)
Mendritzki, Sonja& Schmidt, Saskia& Sczepan, Teresa& Zhu, Xin-Ran& Segelcke, Daniel& Lübbert, Hermann. 2010. Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice. International Journal of Otolaryngology،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-467137
Modern Language Association (MLA)
Mendritzki, Sonja…[et al.]. Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice. International Journal of Otolaryngology No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-467137
American Medical Association (AMA)
Mendritzki, Sonja& Schmidt, Saskia& Sczepan, Teresa& Zhu, Xin-Ran& Segelcke, Daniel& Lübbert, Hermann. Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice. International Journal of Otolaryngology. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-467137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467137