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Fagopyrum tataricum (Buckwheat) Improved High-Glucose-Induced Insulin Resistance in Mouse Hepatocytes and Diabetes in Fructose-Rich Diet-Induced Mice
Joint Authors
Wu, She-Ching
Shen, Siou-Ru
Cheng, Yu-Hsiang
Lee, Chia-Chen
Hsu, Wei-Hsuan
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Fagopyrum tataricum (buckwheat) is used for the treatment of type 2 diabetes mellitus in Taiwan.
This study was to evaluate the antihyperglycemic and anti-insulin resistance effects of 75% ethanol extracts of buckwheat (EEB) in FL83B hepatocytes by high-glucose (33 mM) induction and in C57BL/6 mice by fructose-rich diet (FRD; 60%) induction.
The active compounds of EEB (100 μg/mL; 50 mg/kg bw), quercetin (6 μg/mL; 3 mg/kg bw), and rutin (23 μg/mL; 11.5 mg/kg bw) were also employed to treat FL83B hepatocytes and animal.
Results indicated that EEB, rutin, and quercetin + rutin significantly improved 2-NBDG uptake via promoting Akt phosphorylation and preventing PPARγ degradation caused by high-glucose induction for 48 h in FL83B hepatocytes.
We also found that EEB could elevate hepatic antioxidant enzymes activities to attenuate insulin resistance as well as its antioxidation caused by rutin and quercetin.
Finally, EEB also inhibited increases in blood glucose and insulin levels of C57BL/6 mice induced by FRD.
American Psychological Association (APA)
Lee, Chia-Chen& Hsu, Wei-Hsuan& Shen, Siou-Ru& Cheng, Yu-Hsiang& Wu, She-Ching. 2012. Fagopyrum tataricum (Buckwheat) Improved High-Glucose-Induced Insulin Resistance in Mouse Hepatocytes and Diabetes in Fructose-Rich Diet-Induced Mice. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467154
Modern Language Association (MLA)
Lee, Chia-Chen…[et al.]. Fagopyrum tataricum (Buckwheat) Improved High-Glucose-Induced Insulin Resistance in Mouse Hepatocytes and Diabetes in Fructose-Rich Diet-Induced Mice. Experimental Diabetes Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-467154
American Medical Association (AMA)
Lee, Chia-Chen& Hsu, Wei-Hsuan& Shen, Siou-Ru& Cheng, Yu-Hsiang& Wu, She-Ching. Fagopyrum tataricum (Buckwheat) Improved High-Glucose-Induced Insulin Resistance in Mouse Hepatocytes and Diabetes in Fructose-Rich Diet-Induced Mice. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-467154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467154