Epicutaneous Immunotherapy Compared with Sublingual Immunotherapy in Mice Sensitized to Pollen (Phleum pratense)
Joint Authors
Dioszeghy, Vincent
Puteaux, Emilie
Dupont, Christophe
Benhamou, Pierre-Henri
Dhelft, Véronique
Ligouis, Mélanie
Mondoulet, Lucie
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The aim of this study was to compare the efficacy of epicutaneous immunotherapy (EPIT) to sublingual immunotherapy (SLIT) in a model of mice sensitized to Phleum pratense pollen.
Methods.
BALB/c mice were sensitized by sub-cutaneous route to pollen protein extract mixed treated for 8 weeks, using sham, EPIT, or SLIT.
Measurements involved the serological response and cytokine profile from reactivated splenocytes, plethysmography after aerosol challenge to pollen, cell, and cytokine contents in the bronchoalveolar lavages (BALs).
Results.
After immunotherapy, sIgE was significantly decreased in the treated groups compared to sham (P<0.001), whereas sIgG2a increased with EPIT and SLIT (P<0.001 and P<0.005 versus sham).
Reactivated splenocytes secreted higher levels of Th2 cytokines with sham (P<0.01).
Penh values were higher in sham than EPIT and SLIT.
Eosinophil recruitment in BAL was significantly reduced only by EPIT (P<0.01).
Conclusion.
In this model of mice sensitized to pollen, EPIT was at least as efficient as SLIT.
American Psychological Association (APA)
Mondoulet, Lucie& Dioszeghy, Vincent& Ligouis, Mélanie& Dhelft, Véronique& Puteaux, Emilie& Dupont, Christophe…[et al.]. 2012. Epicutaneous Immunotherapy Compared with Sublingual Immunotherapy in Mice Sensitized to Pollen (Phleum pratense). ISRN Allergy،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467160
Modern Language Association (MLA)
Mondoulet, Lucie…[et al.]. Epicutaneous Immunotherapy Compared with Sublingual Immunotherapy in Mice Sensitized to Pollen (Phleum pratense). ISRN Allergy No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-467160
American Medical Association (AMA)
Mondoulet, Lucie& Dioszeghy, Vincent& Ligouis, Mélanie& Dhelft, Véronique& Puteaux, Emilie& Dupont, Christophe…[et al.]. Epicutaneous Immunotherapy Compared with Sublingual Immunotherapy in Mice Sensitized to Pollen (Phleum pratense). ISRN Allergy. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-467160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467160