Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia
Joint Authors
Guerrouahen, Bella S.
Tabrizi, Arash Rafii
al-Hijji, Ibrahim
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Stem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called “niches.” The best-characterized stem cell is the hematopoietic stem cell (HSC).
Self-renewal and differentiation ability of HSC are regulated by two major elements: endosteal and vascular regulatory elements.
The osteoblastic niche localized at the inner surface of the bone cavity might serve as a reservoir for long-term HSC storage in a quiescent state.
Whereas the vascular niche, which consists of sinusoidal endothelial cell lining blood vessel, provides an environment for short-term HSC proliferation and differentiation.
Both niches act together to maintain hematopoietic homeostasis.
In this paper, we provide some principles applying to the hematopoietic niches, which will be useful in the study and understanding of other stem cell niches.
We will discuss altered microenvironment signaling leading to myeloid lineage disease.
And finally, we will review some data on the development of acute myeloid leukemia from a subpopulation called leukemia-initiating cells (LIC), and we will discuss on the emerging evidences supporting the influence of the microenvironment on chemotherapy resistance.
American Psychological Association (APA)
Guerrouahen, Bella S.& al-Hijji, Ibrahim& Tabrizi, Arash Rafii. 2011. Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia. Stem Cells International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-467173
Modern Language Association (MLA)
Guerrouahen, Bella S.…[et al.]. Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia. Stem Cells International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-467173
American Medical Association (AMA)
Guerrouahen, Bella S.& al-Hijji, Ibrahim& Tabrizi, Arash Rafii. Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia. Stem Cells International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-467173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467173