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Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes
Joint Authors
Gonzalez-Reyes, Susana
Guzmán-Beltrán, Silvia
Pedraza-Chaverri, José
Torres, Martha
Juarez-Figueroa, Ulises E.
Gonzalez, Yolanda
Bobadilla, Karen
Hernández-Sánchez, Fernando
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Nordihydroguaiaretic acid (NDGA) is a natural lignan with recognized antioxidant and beneficial properties that is isolated from Larrea tridentata.
In this study, we evaluated the effect of NDGA on the downregulation of oxidant stress-induced CD33 in human monocytes (MNs).
Oxidative stress was induced by iodoacetate (IAA) or hydrogen peroxide (H2O2) and was evaluated using reactive oxygen species (ROS) production, and cell viability.
NDGA attenuates toxicity, ROS production and the oxidative stress-induced decrease of CD33 expression secondary to IAA or H2O2 in human MNs.
It was also shown that NDGA (20 μM) attenuates cell death in the THP-1 cell line that is caused by treatment with either IAA or H2O2.
These results suggest that NDGA has a protective effect on CD33 expression, which is associated with its antioxidant activity in human MNs.
American Psychological Association (APA)
Guzmán-Beltrán, Silvia& Pedraza-Chaverri, José& Gonzalez-Reyes, Susana& Hernández-Sánchez, Fernando& Juarez-Figueroa, Ulises E.& Gonzalez, Yolanda…[et al.]. 2013. Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-467180
Modern Language Association (MLA)
Guzmán-Beltrán, Silvia…[et al.]. Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-467180
American Medical Association (AMA)
Guzmán-Beltrán, Silvia& Pedraza-Chaverri, José& Gonzalez-Reyes, Susana& Hernández-Sánchez, Fernando& Juarez-Figueroa, Ulises E.& Gonzalez, Yolanda…[et al.]. Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-467180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467180