Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes

Joint Authors

Gonzalez-Reyes, Susana
Guzmán-Beltrán, Silvia
Pedraza-Chaverri, José
Torres, Martha
Juarez-Figueroa, Ulises E.
Gonzalez, Yolanda
Bobadilla, Karen
Hernández-Sánchez, Fernando

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-02-24

Country of Publication

Egypt

No. of Pages

14

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

Nordihydroguaiaretic acid (NDGA) is a natural lignan with recognized antioxidant and beneficial properties that is isolated from Larrea tridentata.

In this study, we evaluated the effect of NDGA on the downregulation of oxidant stress-induced CD33 in human monocytes (MNs).

Oxidative stress was induced by iodoacetate (IAA) or hydrogen peroxide (H2O2) and was evaluated using reactive oxygen species (ROS) production, and cell viability.

NDGA attenuates toxicity, ROS production and the oxidative stress-induced decrease of CD33 expression secondary to IAA or H2O2 in human MNs.

It was also shown that NDGA (20 μM) attenuates cell death in the THP-1 cell line that is caused by treatment with either IAA or H2O2.

These results suggest that NDGA has a protective effect on CD33 expression, which is associated with its antioxidant activity in human MNs.

American Psychological Association (APA)

Guzmán-Beltrán, Silvia& Pedraza-Chaverri, José& Gonzalez-Reyes, Susana& Hernández-Sánchez, Fernando& Juarez-Figueroa, Ulises E.& Gonzalez, Yolanda…[et al.]. 2013. Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-467180

Modern Language Association (MLA)

Guzmán-Beltrán, Silvia…[et al.]. Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-467180

American Medical Association (AMA)

Guzmán-Beltrán, Silvia& Pedraza-Chaverri, José& Gonzalez-Reyes, Susana& Hernández-Sánchez, Fernando& Juarez-Figueroa, Ulises E.& Gonzalez, Yolanda…[et al.]. Nordihydroguaiaretic Acid Attenuates the Oxidative Stress-Induced Decrease of CD33 Expression in Human Monocytes. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-467180

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-467180