Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease

Abstract EN

The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis.

We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease.

The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups).

The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method.

Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation.

Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P<0.001), although no significant difference was observed in the survival rate between the two groups.

In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival.

AST-120 is an effective therapy for delaying the progression of CKD.