![](/images/graphics-bg.png)
Use of Nebulized Amphotericin B in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis
Joint Authors
Proesmans, M.
Vermeulen, F.
De Boeck, K.
Vreys, M.
Source
International Journal of Pediatrics
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Systemic steroids and adjunctive antifungal therapy are the cornerstone in treating allergic bronchopulmonary aspergillosis (ABPA) in the context of CF.
Aim.
Evaluate the use of inhaled amphotericin B (iAMB) as antifungal agent in this context.
Methods.
Report of 7 CF patients with recurrent or difficult to treat ABPA and failure to taper systemic corticosteroids treated with AMB deoxycholate (AMB-d) (Fungizone 25 mg 3× a week) or AMB lipid complex (ABLC) (Abelcet 50 mg twice weekly).
Successful therapy was defined as steroid withdrawal without ABPA relapse within 12 months.
Results.
Therapy was successful in 6 of 7 patients treated with iAMB.
In 5/6, lung function improved.
The patient with treatment failure has concomitant MAC lung infection.
Conclusion.
Inhaled AMB may be an alternative to commonly used adjunctive antifungal therapy in the treatment of ABPA.
More data are needed on safety and efficacy.
American Psychological Association (APA)
Proesmans, M.& Vermeulen, F.& Vreys, M.& De Boeck, K.. 2010. Use of Nebulized Amphotericin B in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis. International Journal of Pediatrics،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-467224
Modern Language Association (MLA)
Proesmans, M.…[et al.]. Use of Nebulized Amphotericin B in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis. International Journal of Pediatrics No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-467224
American Medical Association (AMA)
Proesmans, M.& Vermeulen, F.& Vreys, M.& De Boeck, K.. Use of Nebulized Amphotericin B in the Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis. International Journal of Pediatrics. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-467224
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467224