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Variants of Insulin-Signaling Inhibitor Genes in Type 2 Diabetes and Related Metabolic Abnormalities
Joint Authors
Fiorentino, Teresa Vanessa
Greco, Annalisa
de Lorenzo, Carlo
Mannino, Gaia Chiara
Hribal, Marta Letizia
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Insulin resistance has a central role in the pathogenesis of several metabolic diseases, including type 2 diabetes, obesity, glucose intolerance, metabolic syndrome, atherosclerosis, and cardiovascular diseases.
Insulin resistance and related traits are likely to be caused by abnormalities in the genes encoding for proteins involved in the composite network of insulin-signaling; in this review we have focused our attention on genetic variants of insulin-signaling inhibitor molecules.
These proteins interfere with different steps in insulin-signaling: ENPP1/PC-1 and the phosphatases PTP1B and PTPRF/LAR inhibit the insulin receptor activation; INPPL1/SHIP-2 hydrolyzes PI3-kinase products, hampering the phosphoinositide-mediated downstream signaling; and TRIB3 binds the serine-threonine kinase Akt, reducing its phosphorylation levels.
While several variants have been described over the years for all these genes, solid evidence of an association with type 2 diabetes and related diseases seems to exist only for rs1044498 of the ENPP1 gene and for rs2295490 of the TRIB3 gene.
However, overall the data recapitulated in this Review article may supply useful elements to interpret the results of novel, more technically advanced genetic studies; indeed it is becoming increasingly evident that genetic information on metabolic diseases should be interpreted taking into account the complex biological pathways underlying their pathogenesis.
American Psychological Association (APA)
de Lorenzo, Carlo& Greco, Annalisa& Fiorentino, Teresa Vanessa& Mannino, Gaia Chiara& Hribal, Marta Letizia. 2013. Variants of Insulin-Signaling Inhibitor Genes in Type 2 Diabetes and Related Metabolic Abnormalities. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-467239
Modern Language Association (MLA)
de Lorenzo, Carlo…[et al.]. Variants of Insulin-Signaling Inhibitor Genes in Type 2 Diabetes and Related Metabolic Abnormalities. International Journal of Genomics No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-467239
American Medical Association (AMA)
de Lorenzo, Carlo& Greco, Annalisa& Fiorentino, Teresa Vanessa& Mannino, Gaia Chiara& Hribal, Marta Letizia. Variants of Insulin-Signaling Inhibitor Genes in Type 2 Diabetes and Related Metabolic Abnormalities. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-467239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467239