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Podocyte Protein, Nephrin, Is a Substrate of Protein Tyrosine Phosphatase 1B
Joint Authors
Jiang, Ruihua
Jones, Nina
Takano, Tomoko
Lee, Tae Hoon
Aoudjit, Lamine
New, Laura A.
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glomerular podocytes are critical for the barrier function of the glomerulus in the kidney and their dysfunction causes protein leakage into the urine (proteinuria).
Nephrin is a key podocyte protein, which regulates the actin cytoskeleton via tyrosine phosphorylation of its cytoplasmic domain.
Here we report that two protein tyrosine phosphatases, PTP1B and PTP-PEST negatively regulate nephrin tyrosine phosphorylation.
PTP1B directly binds to and dephosphorylates nephrin, while the action of PTP-PEST is indirect.
The two phosphatases are also upregulated in the glomerulus in the rat model of puromycin aminonucleoside nephrosis.
Both overexpression and inhibition of PTP1B deranged the actin cytoskeleton in cultured mouse podocytes.
Thus, protein tyrosine phosphatases may affect podocyte function via regulating nephrin tyrosine phosphorylation.
American Psychological Association (APA)
Aoudjit, Lamine& Jiang, Ruihua& Lee, Tae Hoon& New, Laura A.& Jones, Nina& Takano, Tomoko. 2011. Podocyte Protein, Nephrin, Is a Substrate of Protein Tyrosine Phosphatase 1B. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-467247
Modern Language Association (MLA)
Aoudjit, Lamine…[et al.]. Podocyte Protein, Nephrin, Is a Substrate of Protein Tyrosine Phosphatase 1B. Journal of Signal Transduction No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-467247
American Medical Association (AMA)
Aoudjit, Lamine& Jiang, Ruihua& Lee, Tae Hoon& New, Laura A.& Jones, Nina& Takano, Tomoko. Podocyte Protein, Nephrin, Is a Substrate of Protein Tyrosine Phosphatase 1B. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-467247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467247