Variability in the Responsiveness to Low-Dose Aspirin : Pharmacological and Disease-Related Mechanisms
Joint Authors
Petrucci, Giovanna
Rocca, Bianca
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The main pharmacological aspects of pharmacodynamics (PD) and pharmacokinetics (PK) of aspirin as antiplatelet agent were unravelled between the late sixties and the eighties, and low-dose aspirin given once daily has been shown to be a mainstay in the current treatment and prevention of cardiovascular disorders.
Nevertheless, several PD and PK aspects of aspirin in selected clinical conditions have recently emerged and deserve future clinical attention.
In 1994, the term “aspirin resistance” was used for the first time, but, until now, no consensus exists on definition, standardized assay, underlying mechanisms, clinical impact, and possible efficacy of alternative therapeutic interventions.
At variance with an undefined aspirin-resistant status, in the last 5 years, the concept of variability in response to aspirin due to specific pathophysiological mechanisms and based on PK and/or PD of the drug has emerged.
This growing evidence highlights the existence and possible clinical relevance of an interindividual variability of pharmacological aspirin response and calls for new, large studies to test new low-dose aspirin-based regimens which may ameliorate platelet acetylation, reduce variability in drug responsiveness, and improve clinical efficacy on selected populations.
American Psychological Association (APA)
Rocca, Bianca& Petrucci, Giovanna. 2012. Variability in the Responsiveness to Low-Dose Aspirin : Pharmacological and Disease-Related Mechanisms. Thrombosis،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-467251
Modern Language Association (MLA)
Rocca, Bianca& Petrucci, Giovanna. Variability in the Responsiveness to Low-Dose Aspirin : Pharmacological and Disease-Related Mechanisms. Thrombosis No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-467251
American Medical Association (AMA)
Rocca, Bianca& Petrucci, Giovanna. Variability in the Responsiveness to Low-Dose Aspirin : Pharmacological and Disease-Related Mechanisms. Thrombosis. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-467251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467251