Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats
Joint Authors
Wu, Yiling
Zhang, Junfang
Tang, Siwen
Wei, Cong
Jia, Zhenhua
Xu, Dengfeng
Wang, Hongtao
Wang, Lei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Qiliqiangxin capsule (QL) was developed under the guidance of TCM theory of collateral disease and had been shown to be effective and safe for the treatment of heart failure.
The present study explored the role of and mechanism by which the herbal compounds QL act on energy metabolism, in vivo, in pressure overload heart failure.
SD rats received ascending aorta constriction (TAC) to establish a model of myocardial hypertrophy.
The animals were treated orally for a period of six weeks.
QL significantly inhibited cardiac hypertrophy due to ascending aortic constriction and improved hemodynamics.
This effect was linked to the expression levels of the signaling factors in connection with upregulated energy and the regulation of glucose and lipid substrate metabolism and with a decrease in metabolic intermediate products and the protection of mitochondrial function.
It is concluded that QL may regulate the glycolipid substrate metabolism by activating AMPK/PGC-1α axis and reduce the accumulation of free fatty acids and lactic acid, to protect cardiac myocytes and mitochondrial function.
American Psychological Association (APA)
Zhang, Junfang& Wei, Cong& Wang, Hongtao& Tang, Siwen& Jia, Zhenhua& Wang, Lei…[et al.]. 2013. Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467307
Modern Language Association (MLA)
Zhang, Junfang…[et al.]. Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-467307
American Medical Association (AMA)
Zhang, Junfang& Wei, Cong& Wang, Hongtao& Tang, Siwen& Jia, Zhenhua& Wang, Lei…[et al.]. Protective Effect of Qiliqiangxin Capsule on Energy Metabolism and Myocardial Mitochondria in Pressure Overload Heart Failure Rats. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-467307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467307