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TLR-Mediated Preterm Birth in Response to Pathogenic Agents
Joint Authors
Nevers, Tania A.
Sharma, Surendra
Thaxton, Jessica E.
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The incidence of preterm birth in developed countries has risen in the past decades.
Underlying causes for this enigmatic pregnancy complication are numerous, yet infectious agents that induce dysregualtion of immunity at the maternal-fetal interface pose one of the most probable causes of preterm birth.
This paper highlights two factors regarding maternal infections that trigger unscheduled inflammatory sequences that are deleterious to the maternal-fetal balance necessary to maintain pregnancy.
Firstly, we discuss the role of Toll-like receptors (TLRs) as sentinels of uterine immunity in the context of response to pathogens.
We highlight the idea that particular TLR activations lead to differential immune cascades that induce preterm birth.
Secondly, two alternative routes of pathogenic entry may prove to be critical for inducing preterm birth via a cytokine storm or a secondary and currently unknown cell-mediated mechanism of uterine inflammation.
This paper summarizes pathways that underlie activation of adverse and diverse immune responses to foreign agents that may result in preterm birth.
American Psychological Association (APA)
Thaxton, Jessica E.& Nevers, Tania A.& Sharma, Surendra. 2010. TLR-Mediated Preterm Birth in Response to Pathogenic Agents. Infectious Diseases in Obstetrics and Gynecology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-467323
Modern Language Association (MLA)
Thaxton, Jessica E.…[et al.]. TLR-Mediated Preterm Birth in Response to Pathogenic Agents. Infectious Diseases in Obstetrics and Gynecology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-467323
American Medical Association (AMA)
Thaxton, Jessica E.& Nevers, Tania A.& Sharma, Surendra. TLR-Mediated Preterm Birth in Response to Pathogenic Agents. Infectious Diseases in Obstetrics and Gynecology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-467323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467323