An Immunohistochemical Study on the Expression of Sex Steroid Receptors in Canine Mammary Tumors
Joint Authors
Varshney, Khub Chandra
Nair, Madhavan Gopalakrishnan
Port Louis, Leena Rajathy
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Steroid hormones are found to play a major role in the genesis and progression of mammary tumors.
The aim of this study was to immunohistochemically detect the presence of estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and progesterone receptor (PR) and also to study the association between these markers in 29 cases of benign (11) and malignant (18) canine mammary tumors.
ERα immunostaining was noticed in only one case of carcinosarcoma specifically in the nuclei of epithelial and a few myoepithelial cells.
ERβ immunostaining was noticed in the nuclei and cytoplasm of epithelial cells and smooth muscles lining the blood vessels.
Immunoexpression of ERβ was 82% in benign tumors and 78% in malignant tumors.
PR immunostaining was expressed in the nuclei of epithelial cells in both benign and malignant tumors.
Among the 15 PR+ cases, 6 (55%) were of benign type, and 9 (50%) were of malignant type.
The most common group of hormone receptor was the ERα−/PR+/ERβ+ (46%) in benign tumors and ERα−/PR−/ERβ+ (38%) in malignant tumors.
Although there was no significant association between ERα and PR with ERβ, the findings indicated that ERβ was consistently expressed in both benign and malignant tumors, irrespective of ERα and PR status.
American Psychological Association (APA)
Port Louis, Leena Rajathy& Varshney, Khub Chandra& Nair, Madhavan Gopalakrishnan. 2012. An Immunohistochemical Study on the Expression of Sex Steroid Receptors in Canine Mammary Tumors. ISRN Veterinary Science،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-467338
Modern Language Association (MLA)
Port Louis, Leena Rajathy…[et al.]. An Immunohistochemical Study on the Expression of Sex Steroid Receptors in Canine Mammary Tumors. ISRN Veterinary Science No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-467338
American Medical Association (AMA)
Port Louis, Leena Rajathy& Varshney, Khub Chandra& Nair, Madhavan Gopalakrishnan. An Immunohistochemical Study on the Expression of Sex Steroid Receptors in Canine Mammary Tumors. ISRN Veterinary Science. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-467338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-467338